[Delta-9-tetrahydrocannabinol pharmacokinetics].
Identifieur interne : 000D44 ( Main/Exploration ); précédent : 000D43; suivant : 000D45[Delta-9-tetrahydrocannabinol pharmacokinetics].
Auteurs : J-P Goullé [France] ; E. Saussereau ; C. LacroixSource :
- Annales pharmaceutiques francaises [ 0003-4509 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Dronabinol.
- chemical , pharmacokinetics : Dronabinol, Psychotropic Drugs.
- chemical , pharmacology : Dronabinol, Psychotropic Drugs.
- metabolism : Marijuana Smoking.
- Absorption, Animals, Humans, Tissue Distribution.
Abstract
Delta-9-tetrahydrocannabinol (Delta-9-THC) is the main psychoactive ingredient of cannabis. Smoking is currently most common use of cannabis. The present review focuses on the pharmacokinetics of THC. The variability of THC in plant material which has significantly increased in recent years leads to variability in tissue THC levels from smoking, which is, in itself, a highly individual process. This variability of THC content has an important impact on drug pharmacokinetics and pharmacology. After smoking THC bioavailability averages 30%. With a 3.55% THC cigarette, a peak plasma level near 160 ng/mL occurs approximately 10 min after inhalation. THC is eliminated quickly from plasma in a multiphasic manner and is widely distributed to tissues, which is responsible for its pharmacologic effects. Body fat then serves as a long-term storage site. This particular pharmacokinetics explains the noncorrelation between THC blood level and clinical effects as is observed for ethanol. A major active 11-hydroxy metabolite is formed after both inhalation and oral dosing (20 and 100% of parent, respectively). The elimination of THC and its many metabolites, mainly THC-COOH, occurs via the feces and urine for several weeks. Thus, to confirm abstinence, urine THC-COOH analysis would be a useful tool. A positive result could be checked by gas chromatography-mass spectrometry THC blood analysis, indicative of a recent cannabis exposure.
DOI: 10.1016/j.pharma.2008.07.006
PubMed: 18847571
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000253
- to stream PubMed, to step Curation: 000253
- to stream PubMed, to step Checkpoint: 000253
- to stream Ncbi, to step Merge: 000218
- to stream Ncbi, to step Curation: 000218
- to stream Ncbi, to step Checkpoint: 000218
- to stream Main, to step Merge: 000D55
- to stream Main, to step Curation: 000D44
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Delta-9-tetrahydrocannabinol pharmacokinetics].</title>
<author><name sortKey="Goulle, J P" sort="Goulle, J P" uniqKey="Goulle J" first="J-P" last="Goullé">J-P Goullé</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacocinétique et de toxicologie cliniques, groupe hospitalier du Havre, BP 24, 76083 Le Havre cedex, France. jgoulle@ch-havre.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de pharmacocinétique et de toxicologie cliniques, groupe hospitalier du Havre, BP 24, 76083 Le Havre cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saussereau, E" sort="Saussereau, E" uniqKey="Saussereau E" first="E" last="Saussereau">E. Saussereau</name>
</author>
<author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="RBID">pubmed:18847571</idno>
<idno type="pmid">18847571</idno>
<idno type="doi">10.1016/j.pharma.2008.07.006</idno>
<idno type="wicri:Area/PubMed/Corpus">000253</idno>
<idno type="wicri:Area/PubMed/Curation">000253</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000253</idno>
<idno type="wicri:Area/Ncbi/Merge">000218</idno>
<idno type="wicri:Area/Ncbi/Curation">000218</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000218</idno>
<idno type="wicri:doubleKey">0003-4509:2008:Goulle J:delta:tetrahydrocannabinol:pharmacokinetics</idno>
<idno type="wicri:Area/Main/Merge">000D55</idno>
<idno type="wicri:Area/Main/Curation">000D44</idno>
<idno type="wicri:Area/Main/Exploration">000D44</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">[Delta-9-tetrahydrocannabinol pharmacokinetics].</title>
<author><name sortKey="Goulle, J P" sort="Goulle, J P" uniqKey="Goulle J" first="J-P" last="Goullé">J-P Goullé</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacocinétique et de toxicologie cliniques, groupe hospitalier du Havre, BP 24, 76083 Le Havre cedex, France. jgoulle@ch-havre.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de pharmacocinétique et de toxicologie cliniques, groupe hospitalier du Havre, BP 24, 76083 Le Havre cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saussereau, E" sort="Saussereau, E" uniqKey="Saussereau E" first="E" last="Saussereau">E. Saussereau</name>
</author>
<author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
</author>
</analytic>
<series><title level="j">Annales pharmaceutiques francaises</title>
<idno type="ISSN">0003-4509</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absorption</term>
<term>Animals</term>
<term>Dronabinol (administration & dosage)</term>
<term>Dronabinol (pharmacokinetics)</term>
<term>Dronabinol (pharmacology)</term>
<term>Humans</term>
<term>Marijuana Smoking (metabolism)</term>
<term>Psychotropic Drugs (pharmacokinetics)</term>
<term>Psychotropic Drugs (pharmacology)</term>
<term>Tissue Distribution</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dronabinol</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dronabinol</term>
<term>Psychotropic Drugs</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dronabinol</term>
<term>Psychotropic Drugs</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Marijuana Smoking</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Absorption</term>
<term>Animals</term>
<term>Humans</term>
<term>Tissue Distribution</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Delta-9-tetrahydrocannabinol (Delta-9-THC) is the main psychoactive ingredient of cannabis. Smoking is currently most common use of cannabis. The present review focuses on the pharmacokinetics of THC. The variability of THC in plant material which has significantly increased in recent years leads to variability in tissue THC levels from smoking, which is, in itself, a highly individual process. This variability of THC content has an important impact on drug pharmacokinetics and pharmacology. After smoking THC bioavailability averages 30%. With a 3.55% THC cigarette, a peak plasma level near 160 ng/mL occurs approximately 10 min after inhalation. THC is eliminated quickly from plasma in a multiphasic manner and is widely distributed to tissues, which is responsible for its pharmacologic effects. Body fat then serves as a long-term storage site. This particular pharmacokinetics explains the noncorrelation between THC blood level and clinical effects as is observed for ethanol. A major active 11-hydroxy metabolite is formed after both inhalation and oral dosing (20 and 100% of parent, respectively). The elimination of THC and its many metabolites, mainly THC-COOH, occurs via the feces and urine for several weeks. Thus, to confirm abstinence, urine THC-COOH analysis would be a useful tool. A positive result could be checked by gas chromatography-mass spectrometry THC blood analysis, indicative of a recent cannabis exposure.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Haute-Normandie</li>
<li>Région Normandie</li>
</region>
<settlement><li>Le Havre</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
<name sortKey="Saussereau, E" sort="Saussereau, E" uniqKey="Saussereau E" first="E" last="Saussereau">E. Saussereau</name>
</noCountry>
<country name="France"><region name="Région Normandie"><name sortKey="Goulle, J P" sort="Goulle, J P" uniqKey="Goulle J" first="J-P" last="Goullé">J-P Goullé</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D44 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D44 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/France |area= LeHavreV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:18847571 |texte= [Delta-9-tetrahydrocannabinol pharmacokinetics]. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18847571" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LeHavreV1
This area was generated with Dilib version V0.6.25. |